Glucagon-like peptide-1 (GLP-1) and glucagon receptor co-agonism is an emerging therapeutic strategy for obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). To examine their distinct and combined metabolic actions in a model reflecting chronic disease, we used diet-induced obese mice that had been maintained on high-fat diet from early adulthood, allowing obesity and ...
Introduction and Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) effectively manage Type 2 Diabetes Mellitus by improving glucose levels, -cell function, and weight reduction. This study evaluated body composition changes after incretin treatments and withdrawal in a diet-induced obese mouse model.
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The large decrease in body weight with glucagon-like peptide-1 (GLP-1) medicines raises concern about a loss of lean body mass (LBM) and skeletal muscle. In this work, we present four pre-clinical studies and a proof-of-concept clinical trial that address this issue. We report that in obese mice, GLP-1 medicines predominantly reduce body fat alongside a small but significant decrease in LBM ...
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I provide details regarding the development of GLP-1 receptor agonists for anti-obesity therapy and discuss the possible mechanism behind their beneficial effects on adverse cardiovascular events.
The purpose of this study was to explore how semaglutide, a GLP-1RA, regulates serum metabolism and gut microbiota to improve obesity in mice and whether fecal microbiota transplantation (FMT) can transmit the beneficial effects of semaglutide to recipient mice.
Diet-induced obese (DIO) mice were chronically treated with either the long-acting GLP-1R agonist liraglutide, the MC4R agonist RM-493 or a combination of RM-493 and liraglutide.
A keto diet is a very low carb, high fat diet. Get started on keto with delicious recipes, amazing meal plans, health advice, and inspiring videos to help you succeed.PLoS One 2015: Dietary intervention for overweight and obese adults: Comparison of low carbohydrate and low fat diets.
