Frozen prey thawed in the refrigerator overnight has less chance to cause problems than one thawed on the countertop. A feeder rat or mouse must be treated like a potentially hazardous food (PHF) for human comsuption.
Warm Water Thawing: Avoid using warm or hot water to thaw frozen rats, as this can cause the meat to cook on the outside while remaining frozen on the inside. It can also destroy the natural scent and texture of the prey.
Lets talk about the benefits of offering frozen / thawed rodents, as well as the feeding techniques involved. Frozen Rats are More Convenient. We will get to the safety issues in a moment. But first, lets talk about the convenience of using frozen rats as a food source for your snake.

I suspect live rats are more of a reaction to food while Frozen Thawed are more of a hunger thing (*non scientific opinion). They eat when they need to as opposed to eating just to eat. Would love to know others experiences here.
Thawing and Handling Frozen Rats. Introducing Frozen Rats to Your Ferret. Potential Risks and Mitigation Strategies.FAQs About Feeding Ferrets Frozen Rats. Can ferrets eat frozen food directly?

Are There Any Risks With Frozen/Thawed? Now that Ive outlined how f/t is the safer and more humane way to go, Ill go over the couple of risks that may come along with feeding frozen prey items. Most important is making sure that the prey item is thoroughly defrosted.
How do you feed a snake a rat? Like threading a needle with natures precision, youll thaw the frozen rat completely, warm it with hot water. Then use tongs to dangle it near your snakes head until it strikes, a process that requires precision and patience.

Feeding frozen-thawed is not as natural to the snake, or any creature, for that matter.The entire article is about feeding frozen mice, rats, and other feeders to snakes. I am in no way condoning feeding live feeders, but sometimes you do what you have to in order to feed a snake.