The beta cell function model employed was originally developed and applied in cohorts of individuals with normal or impaired glucose tolerance and type 2 diabetes [31][32][33].
The nature of the progressive -cell failure occurring as normal glucose tolerant (NGT) individuals progress to type 2 diabetes (T2DM) is incompletely understood.
Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired -cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study.
This particular example perfectly highlights why Beta-Cell Function In Subjects Spanning The Range From Normal Glucose is so captivating.
One-hour plasma glucose identifies insulin resistance and beta-cell dysfunction in individuals with normal glucose tolerance: cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study.
The assessment of -cell function, defined as the relationship between insulin secretion rate (ISR) and plasma glucose, is not standardized and often involves any of a number of -cell function indices.
Aim: This study was designed to assess -cell function and insulin sensitivity indices among normal glucose tolerance (NGT) subjects stratified by 1-h plasma glucose (1hPG) values during an oral glucose tolerance test (OGTT).
Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, and DeFronzo RA. -cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.
Beta cell function in subjects spanning the range from normal glucose tolerance to overt diabetes mellitus: a new analysis.Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care.
